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Diagnostic Technologies and Molecular and Cellular Profiling: Determinants of Patient Prognosis

Clinical significance of IDO (Indoleamine-2, 3-dioxygenase), nuclear factor-kB (NFkB) and Akt2 expression in various pathological types of ovarian cancers

Jikei University, Tokyo, Japan

Abstract

A59

Purpose: We previously reported that Indoleamine-2,3-dioxygenase (IDO) was positively associated with paclitaxel resistance and that IDO served as a marker of poor prognosis in serous ovarian cancers. In this study, we examined key molecules associated with IDO including NFkB and Akt2 by immunohistochemical analysis in 120 various pathological types of ovarian cancers. Methods: Expression of IDO, NFkB and Akt2 was examined by immunohistochemical analysis in 120 ovarian cancers including 37 serous adenocarcinomas (SA), 64 clear cell adenocarcinomas (CCA) and 19 endometrioid adenocarcinomas (EA). We established scoring system for IDO, NFkB, and Akt2 expression based on the staining pattern and intensity. The relationship between expression of the 3 molecules and clinicopathological parameters was analyzed. Results: 1) The Kaplan-Meier survival curve showed significant inverse relationship between staining score and overall survival of 33 advanced SA cases who undertook optimal surgery and Paclitaxel-Carboplatin as a first line chemotherapy. 2) There was significant association between Akt2 staining score and overall survival in 3 pathological types (SA,CCA, and EA) (P=0.0043). 3) No association was detected between NFkB staining score and overall survival of each pathological type of ovarian cancers. 4) There was no correlation among expression of IDO, Akt2 and NFkB proteins. Conclusion: IDO expression was positively associated with impaired survival only in serous type of ovarian cancer. Akt2 was also positively associated with overall survival in epithelial ovarian cancer. Nevertheless, IDO may not exist on the common signal pathway which Akt2 and NFkB are asssociated.